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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2418903Generated: October 25, 2026

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine → 2-(Trifluoromethyl)pyridine-4-boronic acid, pinacol ester

https://huagongshe.com/reaction/2418903

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridineHCID 2734648—
ReactantCID 89601280HCID 89601280—
Reagenttert-Butyl hydroperoxideHCID 6410—
SolventWaterHCID 962—
SolventDichloromethaneHCID 6344—
Product2-(Trifluoromethyl)pyridine-4-boronic acid, pinacol esterHCID 4578570850%
Product5-(Trifluoromethyl)pyrimidine-2-carbonitrileHCID 5341832831%

Reaction Conditions

Temperature50 °C

Provenance & Evidence

DOI10.1038/nature11680
Source datasetMinisci dataset from Roche
ORD IDord-872cd33066aa40a991c46777b535e5b7
Source noteMinisci dataset from Roche