Formaldehyde → 2,4-Thiazolidinedione, 3-[[(2-methylphenyl)amino]methyl]-

Participants

Reaction Steps

A mixture of 10.7 g of o-toluidine, 3.3 g. of paraformaldehyde, and 11.7 g of 2,4-thiazolidinedione in 100 ml of absolute ethanol was refluxed 5 hrs under nitrogen atmosphere. On cooling, the resulting precipitate was filtered off to give 22.1 g of N-(2-methylphenylaminomethyl)-2,4-thiazolidinedione, mp 109°-111° C; identified by IR and NMR.

Provenance & Evidence