Formaldehyde → HCID 1379704, compound
Reaction equation
[S:1]1[CH2:5][C:4](=[O:6])[NH:3][C:2]1=[O:7].[CH3:8][O:9][C:10]1[C:11]([NH2:16])=[CH:12][CH:13]=[CH:14][CH:15]=1.[CH2:17]=O>C(O)C>[CH3:8][O:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[NH:16][CH2:17][N:3]1[C:4](=[O:6])[CH2:5][S:1][C:2]1=[O:7]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 30 °C
Procedure
A mixture of 13.3 g of 2,4-thiazolidinedione and 12.3 g of o-anisidine was dissolved in 100 ml of warm ethanol at 55° to 70° C. The solution was cooled to about 30° C, and 9.1 ml of 37% formaldehyde solution was added and stirred overnight. The resulting precipitate was filtered to give 22.5 g of N-(2-methoxyphenylaminomethyl)-2,4-thiazolidinedione, mp 88.5°-91° C; identified by IR and NMR.
Workup
- filtrationThe resulting precipitate was filtered
Sources & evidence
- ORD record
- ord-e58ea9dd923c464eb4c38d52c65a5c5f
- Source dataset
- uspto-grants-1978_08
- Patent number
- US04104051
Reaction notes
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