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Hydrogen Bromide → 3,4-Dihydroxyphenyl-3-pyridyl ketone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrogen Bromide | HCID 260 | — |
| 反応物 | Piconol | HCID 11474 | — |
| 反応物 | 3-Bromopyridine | HCID 12286 | — |
| 反応物 | (3,4-Dimethoxyphenyl)(pyridin-3-yl)methanol | HCID 13475606 | — |
| 反応物 | 3,4-Dimethoxyphenyl-3-pyridyl ketone | HCID 53681602 | — |
| 生成物 | 3,4-Dihydroxyphenyl-3-pyridyl ketone | HCID 136409716 | — |
反応手順
3,4-Dimethoxyphenyl-3-pyridyl carbinol was obtained as an oil as described for the preceding 2-pyridyl carbinol of Example 40 except that 3-bromopyridine is used in place of 2-bromopyridine. This carbinol was converted to 3,4-dimethoxyphenyl-3-pyridyl ketone, mp 76°-78° C and reacted with hydrobromic acid to give 3,4-dihydroxyphenyl-3-pyridyl ketone, mp 182°-184° Crown ether formation as described in Example 40 gave 1-(2,3,5,6,8,9,11,12,14,15-decahydro-1,4,7,10,13,16 hexaoxacyclooctadecin-18-yl)-1-(3-pyridyl)-methanone, mp 98°-100° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04104275 |
| 出典データセット | uspto-grants-1978_08 |
| ORD ID | ord-3fdc51ac73944451a16349151bf7e188 |
| 出典メモ | uspto-grants-1978_08 |