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Chloroform → 2-Amino-N-(2-chlorophenyl)-3-trifluoromethylbenzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Chloroform | HCID 6212 | — |
| 反応物 | 2-Chloroaniline | HCID 7240 | — |
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | 2-Amino-3-(trifluoromethyl)benzoic acid | HCID 604569 | — |
| 溶媒 | Benzene | HCID 241 | — |
| 生成物 | 2-Amino-N-(2-chlorophenyl)-3-trifluoromethylbenzamide | HCID 22316578 | 78% |
反応手順
Prepared according to Procedure A using 3-trifluoromethylanthranilic acid (2.0 g, 9.75 mmol) and SOCl2 (1.8 mL, 24.4 mmol) in benzene (50 mL), followed by 2-chloroaniline (2.1 mL, 19.5 mmol) and CHCl3 (50 mL). The product was purified by recrystallization from MeOH to provide 2.38 g yellow crystals (78%). 1H NMR (CDCl3) δ: 8.40 (dd, J=1.4, 8.3 Hz, 1H); 8.25 (br s, 1H); 7.71 (d, J=7.8 Hz, 1H); 7.60 (d, J=7.8 Hz, 1H); 7.43 (dd, J=1.4, 8.0 Hz, 1H); 7.34 (dt, J=1.3, 7.9 Hz, 1H); 7.11 (dt, J=1.5, 7.7 Hz, 1H); 6.77 (t, J=7.8 Hz, 1H); 6.24 (br s, 2H). MS (ES): m/z 315.0 (M+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08653077B2 |
| 出典データセット | uspto-grants-2014_02 |
| ORD ID | ord-3d17d98cd13b4a7e9afbf2cd71c6377d |
| 出典メモ | uspto-grants-2014_02 |