HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2419002Generated: October 29, 2026
Ethanol → 5-benzyl-6-methyl-2-methylsulfanyl-1H-pyrimidin-4-one
https://huagongshe.com/reaction/2419002
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 5-Benzyl-6-methylthiouracil | HCID 697326 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5-benzyl-6-methyl-2-methylsulfanyl-1H-pyrimidin-4-one | HCID 135422583 | — |
Reaction Steps
5-Benzyl-6-methylthiouracil (6.0 gms) and sodium hydroxide (1.06 gms) were dissolved in water (30 mls). The solution was cooled and ethanol (60 mls) and methyl iodide (3.67 gms) added with stirring. The mixture was heated at 60° C for 178 hour, cooled and the resulting solid collected and water-washed. A second crop of solid was obtained by acidification of the filtrate to pH=4 with acetic acid. Recrystallisation from ethanol produced 5-benzyl-6-methyl-2-methylthio-4-pyrimidone (5.53 gms) m.p. = 220°-221.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04104381 |
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| Source dataset | uspto-grants-1978_08 |
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| ORD ID | ord-bfcd48df539e4941be1a51e6bed0d443 |
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| Source note | uspto-grants-1978_08 |
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