Hydrochloric Acid → 1-(3-Chloro-4-cyclohexylphenyl)-3-(diethylamino)-1-propanone

Participants

Reaction Steps

54 g of diethylamine hydrochloride, 100 g of 3-chloro-4-cyclohexyl-acetophenone and 15.1 g of paraformaldehyde in 75 ml of absolute ethanol were heated under reflux for 4 hours in the presence of 1.5 ml of 10 N hydrochloric acid. When the reaction was complete, the solvent was evaporated over a water bath under the vacuum produced by a water-jet pump, and the residue was then recrystallized from acetone. 116 g (a yield of 76.5% of theory) of 3-chloro-4-cyclohexyl-1-(3-diethylamino-1-oxo-propyl)-benzene were obtained; the product had a melting point of 156°-158° C (with decomposition).

Provenance & Evidence