HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-carboethoxy-11-oxo-11H-pyrido[2,1-b]quinazoline-8-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethanol | HCID 702 | — |
| Reactant | 6-Chloronicotinic acid | HCID 79222 | — |
| Reactant | 2-Aminoterephthalic acid | HCID 2724822 | — |
| Product | 3-carboethoxy-11-oxo-11H-pyrido[2,1-b]quinazoline-8-carboxylic acid | HCID 20316840 | — |
Reaction Steps
A mixture of 2.00g (11.1 mmol) of 2-aminoterephthalic acid, 1.73g (11.1 mmol) of 6-chloronicotinic acid, 2.5ml of conc. HCl and 25ml of ethanol was heated at reflux for 67 hours. The mixture was cooled and filtered to give 0.90g of solid, mp. 275°-324°. The crude material was recrystallized from 1-propanol and gave 0.40g of the mono-esterified product, mp. 283°-293° dec.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04104389 |
| Source dataset | uspto-grants-1978_08 |
| ORD ID | ord-93063648ed9140e9bc35bc3b418620f1 |
| Source note | uspto-grants-1978_08 |