HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 2,3-methylenedioxy-11-oxo-11H-pyrido[2,1-b]quinazoline-6-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 2-Chloronicotinic acid | HCID 76258 | — |
| Reactant | Methyl 6-amino-1,3-benzodioxole-5-carboxylate | HCID 290838 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2,3-methylenedioxy-11-oxo-11H-pyrido[2,1-b]quinazoline-6-carboxylic acid | HCID 20316839 | — |
Reaction Steps
A mixture of 2.00g (10.4 mmol) of methyl 2-amino-4,5-methylenedioxybenzoate, 1.67g (10.4 mmol) of 2-chloronicotinic acid and 50mg of KI was heated at 170° for 1 hour. The fusion or melt gradually solidified to an orange cake. The solid material was heated in boiling methanol (250 ml) and then filtered to yield 1.60g of crude product, mp. 273°-280° dec. The analytical sample was obtained by recrystallization from DMF, mp. 300°-304° dec.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04104389 |
| Source dataset | uspto-grants-1978_08 |
| ORD ID | ord-6c4ebe5621724a688721fa60eaf7865f |
| Source note | uspto-grants-1978_08 |