Hydrochloric Acid → HCID 20316639, compound

Participants

Reaction Steps

A 4 g sample of 7,8-dihydroxy-1-(p-methylthiophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine is slurred in 25 ml of acetone and 0.8 g ( ~ 10% excess) of ethylene oxide is added. The mixture is placed in a pressure bottle and stirred at ambient temperature for about 40 hours. The reaction mixture is then heated to 60°-80° for 30 minutes, cooled and filtered. Concentration of the filtrate gives a solid which is taken up in ethyl acetate and reprecipitated with ether. The solid thus obtained is dissolved in ethanol and treated with ethereal hydrogen chloride to give 7,8-dihydroxy-3-(2-hydroxyethyl)-1-(p-methylthiophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride.

Provenance & Evidence