Boron tribromide → HCID 20316636, compound

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Reaction Steps

Substituting a stoichiometric quantity of 2-fluoro-3,4-dimethoxyphenethylamine in the synthetic procedures of Example 1 gives 6-fluoro-7,8-dimethoxy-1-(p-methylthiophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine. Hydrolysis with boron tribromide as disclosed above gives 6-fluoro-7,8-dihydroxy-1 -(p-methylthiophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine. Substituting 2-trifluoromethyl-3,4,-dimethoxyphenethylamine, prepared via 2-trifluoromethyl-3,4,-dimethoxytoluene, in Example 1 gives 6-trifluoromethyl-7,8-dimethoxy-1-(p-methylthiophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine and hydrolysis with boron tribromide gives 6-trifluoromethyl-7,8-dihydroxy-1-(p-methylthiophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine.

Provenance & Evidence