HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 4-(Pyridin-2-yl)butan-1-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-(Pyridin-2-yl)butanenitrile | HCID 15032256 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 4-(Pyridin-2-yl)butan-1-amine | HCID 13511083 | 44.7% |
Reaction Steps
2-(3-cyanopropyl)pyridine (14.6 g) in dry ether (100 ml) is added dropwise to a stirred suspension of lithium aluminium hydride (9.5 g) in dry ether (300 ml). The mixture is heated under reflux for 3 hours, cooled and treated successively with water, aqueous sodium hydroxide and water. Extraction with chloroform, followed by fractionation affords 2-(4-aminobutyl)pyridine (6.7 g), b.p. 100°-101° C./1.0 mm.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04104382 |
| Source dataset | uspto-grants-1978_08 |
| ORD ID | ord-acbd0e9ad9d5418c8a540e38b836c481 |
| Source note | uspto-grants-1978_08 |