(5-Amino-1,3,4-thiadiazol-2-yl)methanol → HCID 178486112, compound

HRID 2419044Notes

Reaction equation

HRID 2419044 reaction equation
[CH3:1][NH:2][C:3]([NH:5][CH2:6][CH2:7]OCC1N=CNC=1)=[S:4].N[C:16]1[S:17][C:18]([CH2:21]O)=NN=1>>[CH3:1][NH:2][C:3]([NH:5][CH2:6][CH2:7][CH2:16][S:17][CH2:18][C:21]1[N:5]=[CH:3][NH:2][CH:1]=1)=[S:4]

Participants

3

Reactant 2

HCID 11062424(5-Amino-1,3,4-thiadiazol-2-yl)methanolHCID 178486116HCID 178486116, compound

Product 1

HCID 178486112HCID 178486112, compound

Procedure

By the method of Example 58 (i) and (ii) 4(5)-hydroxymethylimidazole was converted first to the intermediate 4(5)-[(3-aminopropyl)thiomethyl]-imidazole dihydrobromide and thence to the title compound (m.p. 118°-120° C, after recrystallisation from water).

Sources & evidence

ORD record
ord-2779f151de6b45d6b4500a64c77f7475
Source dataset
uspto-grants-1978_08
Patent number
US04104382

Reaction notes

Loading…