Ethyl isothiocyanate → HCID 178465516, compound

Participants

Reaction Steps

(b)(i) A solution of 4-methyl-5-[(2-aminoethyl)thiomethyl]-imidazole (6.9 g) and ethyl isothiocyanate (3.84 g) in ethanol was heated under reflux for 2 hours. Concentration followed by recrystallisation of the residue from aqueous ethanol gave N-ethyl-N'-[2-((4-methyl-5-imidazoly)methylthio)ethyl]thiourea (9.0 g), m.p. 140°-141°. (Found: C, 46.5; H, 7.1; N, 21.7; S, 25.1. C10H18N4S2 requires: C, 46.5; H, 7.0; N, 21.7; S, 24.8).

Provenance & Evidence