Ethylamine → N-cyano-N'-ethyl-N"-[2-(2-thiazolylmethylthio)ethyl]guanidine

HRID 2419063Notes

Reaction equation

HRID 2419063 reaction equation
[C:1]([NH:3][C:4](=[N:7][CH2:8][CH2:9][S:10][CH2:11][C:12]1[S:13][CH:14]=[CH:15][N:16]=1)SC)#[N:2].[NH2:17][CH2:18][CH2:19]SCC1SC=CN=1.C(N)C>C(O)C>[C:1]([NH:3][C:4]([NH:17][CH2:18][CH3:19])=[N:7][CH2:8][CH2:9][S:10][CH2:11][C:12]1[S:13][CH:14]=[CH:15][N:16]=1)#[N:2]

Participants

5

Reactant 3

HCID 6341EthylamineHCID 129234032-[(Thiazol-2-yl)methylthio]ethylamineHCID 20427996N-cyano-N'-[2-(2-thiazolylmethyl-thio)ethyl]-S-methylisothiourea

Product 1

HCID 54127424N-cyano-N'-ethyl-N"-[2-(2-thiazolylmethylthio)ethyl]guanidine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

Reaction of N-cyano-N'-[2-(2-thiazolylmethylthio)ethyl]-S-methylisothiourea, prepared by reacting 2-[(2-aminoethyl)thiomethyl]thiazole with dimethyl-N-cyanoimidothio carbonate in ethanol by the procedure of Example 97, with ethylamine in ethanol under reflux for 8 hours gives N-cyano-N'-ethyl-N"-[2-(2-thiazolylmethylthio)ethyl]-guanidine.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-6c8b48b244514870890afc9f0b0f4497
Source dataset
uspto-grants-1978_08
Patent number
US04104382

Reaction notes

Loading…