Ethanol → HCID 20313833, compound

Participants

Reaction Steps

A solution of 4-[(1,3-benzodithiol-2-ylidene)amino]butanoic acid, ethyl ester (3g, prepared as described in Example 5) and sodium hydroxide (427 mg) in 80% aqueous ethanol (50 ml) is stirred at room temperature for seven days. The reaction mixture is concentrated in vacuo and the residue triturated with two 50 ml portions of hot benzene. The solid residue is dissolved in 100 ml of water, filtered through Celite, and the filtrate treated with 10% hydrochloric acid until the pH is 4. The solid precipitate is collected by filtration and washed on the filter with water. Recrystallization of the solid product from chloroform yields 1.3g of the title compound, melting point 140°-142° C.

Provenance & Evidence