反应详情

A slurry of 2.0 g of 3-[(1,3-benzodithiol-2-ylidene)amino]-2-thioxo-4-thiazolidinone (see example 37), valeraldehyde (10 ml, excess) and acetic acid/piperidine (2:1) (10 drops) in anhydrous glyme (400 ml) is heated at reflux for 18 hours. The reaction mixture is chilled in an ice bath and the resultant precipitate collected by filtration. This precipitate (1.6 g) is recrystallized from 50 ml of dimethylformamide to yield 1.1 g of the title compound, melting point 210°-212° C.

1. temperatureat reflux for 18 hours
2. temperatureThe reaction mixture is chilled in an ice bath
3. filtrationthe resultant precipitate collected by filtration
4. customThis precipitate (1.6 g) is recrystallized from 50 ml of dimethylformamide