Glyphosate → HCID 20314767, compound

Participants

Reaction Steps

To a solution of N-phosphonomethylglycine (8.5 grams, 0.05 mole) in 30 ml. of water is added 50% aqueous sodium hydroxide (8.0 grams). The solution is cooled, and 1,2-butylene oxide (3.6 grams, 0.05 mole) is added, after which the solution is rotated overnight on a polymer wheel. Additional amounts of 1,2-butylene oxide are added to complete the reaction, and any unreacted butylene oxide is then extracted with ethyl ether and benzene. A portion of the reaction product is diluted with water and passed through a column of ion exchange resin in the acid form. Cuts 3 through 20 are collected, combined and evaporated to dryness to give 6-ethyl-4-phosphonomethyl-2-morpholinone as a friable glassy solid.

Provenance & Evidence