Acetamide → Acetamidoglycolic acid

HRID 2419237Notes

Reaction equation

HRID 2419237 reaction equation
[C:1]([OH:5])(=[O:4])[CH:2]=[O:3].[C:6]([NH2:9])(=[O:8])[CH3:7]>C(O)(=O)C>[C:6]([NH:9][CH:2]([OH:3])[C:1]([OH:5])=[O:4])(=[O:8])[CH3:7]

Participants

4

Reactant 2

HCID 178AcetamideHCID 760Glyoxylic Acid

Product 1

HCID 14212846Acetamidoglycolic acid

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

An acetic acid solution of acetamidoglycolic acid is prepared by distilling under vacuum without exceeding 40° C the water from a mixture of 74 g of aqueous solution of 50% glyoxylic acid (0.5 mole) and 29.55 g of acetamide (0.5 mole).

Workup

  1. distillationby distilling under vacuum
  2. customwithout exceeding 40° C

Sources & evidence

ORD record
ord-6c3bddeacab34903918aaa0ed054350c
Source dataset
uspto-grants-1978_08
Patent number
US04105690

Reaction notes

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