tert-Butyl acetate → HCID 20315612, compound

Participants

Reaction Steps

A solution of bromine (5.4g.) in benzene (50ml.) was added dropwise over 1 hour to a stirred solution of diethyl 4-acetylphenoxymalonate (10.0g.) and t-butyl acetate (3.95g.) in benzene (200ml.). The solution was stirred for 30 minutes, washed with N-sodium bicarbonate solution (1 × 30ml.), water (3 × 40ml.), dried and evaporated. The residue was chromatographed on silica to give diethyl 4-(bromoacetyl)phenoxymalonate, m.p. 55°-58° C.

Provenance & Evidence