反应详情

Pyridine (40ml.) was added to a stirred mixture of methyl 4-(aminoacetyl)phenoxyacetate hydrochloride (5.2g.) and ethyl chloroformate (2.3g.). An exothermic reaction occurred and was allowed to continue until a homogeneous solution was obtained. This solution was then cooled and the solid residue which formed was first separated, and then washed successively with ether (2 × 30ml.), water (2 × 30ml.) and ether (2 × 30ml.), before recrystallisation from toluene to give methyl 4-[N-(ethoxycarbonyl)aminoacetyl]-phenoxyacetate (4.7g.), m.p. 128°-129° C.

1. customAn exothermic reaction
2. customwas obtained
3. temperatureThis solution was then cooled
4. customthe solid residue which formed
5. washwashed successively with ether (2 × 30ml.), water (2 × 30ml.) and ether (2 × 30ml.), before recrystallisation from toluene