benzyl (2S)-2-aminopropanoate → HCID 178447405, compound

HRID 2419388Notes

Reaction equation

HRID 2419388 reaction equation
C([O:8][C:9](=[O:22])[C@H](CCCNC(=N)N)N[N+]([O-])=O)C1C=CC=CC=1.C(OC(=O)[C@H](C)N)C1C=CC=CC=1.C([O:43][C:44](=[O:67])[C@H:45]([CH2:60][CH2:61][CH2:62][NH:63][C:64](=[NH:66])[NH2:65])[N:46]([N+]([O-])=O)[C:47](=[O:56])[CH:48]([CH3:55])[CH2:49][CH2:50]C(OC)=O)C1C=CC=CC=1.COC(CCC(C)C(N[C@H](C(O)=O)CCCNC(=N)N)=O)=O.C(CCC(C)C(N[C@H](C(O)=O)CCCNC(=N)N)=O)(O)=O>>[C:9]([CH:61]([CH2:62][NH:63][C:64](=[NH:66])[NH2:65])[CH2:60][C@@H:45]([C:44]([OH:43])=[O:67])[NH:46][C:47](=[O:56])[CH:48]([CH3:55])[CH2:49][CH3:50])([OH:22])=[O:8]

Participants

6

Reactant 5

HCID 726858benzyl (2S)-2-aminopropanoateHCID 178447599HCID 178447599, compoundHCID 178500357HCID 178500357, compoundHCID 178500358HCID 178500358, compoundHCID 178512944HCID 178512944, compound

Product 1

HCID 178447405HCID 178447405, compound

Procedure

By substituting nitro-L-arginine benzyl ester for the L-alanine benzyl ester in the procedure of Example 23, and then treating the product by the procedures of Examples 24 and 26, Nα -(4-methoxycarbonyl-2-methylbutanoyl)-nitro-L-arginine benzyl ester, Nα -(4-methoxycarbonyl-2-methylbutanoyl)-L-arginine, and Nα -(4-carboxy-2-methylbutanoyl)-L-arginine are obtained.

Workup

  1. customare obtained

Sources & evidence

ORD record
ord-3c1d709c85fd43cdb6ef54bba328f3e5
Source dataset
uspto-grants-1978_08
Patent number
US04105789

Reaction notes

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