Methacrylic Acid → 3-(Acetylthio)-2-methylpropanoic acid

HRID 2419420Notes

Reaction equation

HRID 2419420 reaction equation
[C:1]([OH:4])(=[S:3])[CH3:2].[C:5]([OH:10])(=[O:9])[C:6]([CH3:8])=[CH2:7]>>[C:1]([S:3][CH2:7][CH:6]([CH3:8])[C:5]([OH:10])=[O:9])(=[O:4])[CH3:2]

Participants

3

Reactant 2

HCID 4093Methacrylic Acid2×HCID 178418634HCID 178418634, compound

Product 1

HCID 1180733-(Acetylthio)-2-methylpropanoic acid

Procedure

A mixture of thioacetic acid (50 g.) and methacrylic acid (40.7 g.) is heated on the steam bath for one hour and then stored at room temperature for 18 hours. After confirming by nmr spectroscopy that complete reaction of the methacrylic acid has been achieved, the reaction mixture is distilled in vacuo and the desired 3-acetylthio-2-methylpropanoic acid is separated in the fraction with boiling point 128.5°-131° (2.6 mmHg.), yield 64 g.

Workup

  1. temperatureis heated on the steam bath for one hour
  2. distillationthe reaction mixture is distilled in vacuo
  3. customthe desired 3-acetylthio-2-methylpropanoic acid is separated in the fraction with boiling point 128.5°-131° (2.6 mmHg.), yield 64 g

Sources & evidence

ORD record
ord-7b1297bf50f04e18942025691ea22326
Source dataset
uspto-grants-1978_08
Patent number
US04105776

Reaction notes

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