HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-(2-Methyl-3-sulfanylpropanoyl)-L-proline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1-[3-(tetrahydropyran-2-ylthio)-2-methylpropanoyl)-L-proline | HCID 22804599 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-(2-Methyl-3-sulfanylpropanoyl)-L-proline | HCID 12877547 | — |
Reaction Steps
A solution of 1-[3-(tetrahydropyran-2-ylthio)-2-methylpropanoyl]-L-proline (1 g.) in a mixture of methanol (25 ml.) and concentrated hydrochloric acid (25 ml.) is stored at room temperature for 30 minutes. The solvents are removed in vacuo to yield 1-(3-mercapto-2-methylpropanoyl)-L-proline. Rf : 0.35 (silica gel, Benzene/acetic acid, 3:1), Rf 0.5 (silica gel, Methyl-ethylketone/acetic acid/pyridine/water 14:1:2:1) identical to the compound of Example 34.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04105776 |
| Source dataset | uspto-grants-1978_08 |
| ORD ID | ord-e7beaac60c234e028b76a154f3072979 |
| Source note | uspto-grants-1978_08 |