Reaction Steps
In the same manner, by using an appropriate amine of formula R16NH2 but replacing 4-oxo-4H,5H-[1]benzothiopyrano[4,3-b]pyran-2-carboxylic acid with an equivalent amount of one of the 4-oxo-tetrahydro-4H,5H-naphtho[2,1-b] or [2,3-b] or [1,2-b]thiopyrano[2,3-d]pyran-2-carboxylic acids (described in Example 79), 4-oxo-1,4,9,10,11,12-hexahydro-5H-naphtho[1',2' : 5,6]thiopyrano[4,3-b]pyridine-2-carboxylic acid (l; R3, R4, R5 and R15 = H, R1 and R2 together form a CH2CH2CH2CH2 chain, X = S and Y = NH), 4-oxo-1,4,8,9,10,11-hexahydro-5H-naphtho[2', 3' : 5,6]thiopyrano]4,3-b]pyridine-2-carboxylic acid (l; R1, R4, R5 and R15 = R2 and R3 together form a CH 2 CH2CH2CH2 chain, X = S and Y = NH), 4-oxo-1,4,7,8,9,10-hexahydro-5H-naphtho[2',1': 5,6]thiopyrano[4,3-b]pyridine-2-carboxylic acid (l; R1, R2, R5 and R15 = H, R3 and R4 together form a CH2CH2CH2CH2 chain, X = S and Y = NH), 1-ethyl-4-oxo-1,4,8,9,10,11-hexahydro-5H-naphtho[2', 3' : 5,6]thiopyrano[4,3-b]pyridine-2-carboxylic acid-6,6-dioxide (l; R1, R4, R5 and R15 = H, R2 and R3 together form a CH2CH2CH2CH2 chain, X = SO2 and Y = NC2H5) and 3-methoxymethyl-4-oxo-1,4,9,10,11,12-hexahydro-5H-naphtho[1', 2' : 5,6]thiopyrano[4,3-b]pyridine-2-carboxylic acid-6,6-dioxide (l; R3, R4 and R15 = H, R1 and R2 together form a CH2CH2CH2CH2 chain, R5 = CH2OCH3, X = SO2 and Y = NH) are obtained, respectively.
