Hydrazine → HCID 131711196, compound

Participants

Reaction Steps

Box-Lys(Z)-Asn-Ala-OBzl (XXIV) (2.3g, 3.5 mmol) was dissolved in MeOH (20 ml) with heating and treated with H2NNH2 (1.1 ml) at 4° C for 72 hr. The precipitated product was filtered and washed with MeOH and ether, yield 1.0g (49.3%). The white powder was crystallized from DMF with isopropanol; mp 177°-180° C; [α]D25 -14.9° (c 1.5, DMF). Anal. Calcd for C26H41N7O8 (579.67): C, 53.87; H, 7.13; N, 16.91. Found: C, 53.75; H, 7.19; N, 17.00.

Provenance & Evidence