HCID 4408645, compound → HCID 20313364, compound

Participants

Reaction Steps

A mixture of 21.8 g of ethyl (2-ethylthio-2-methylpropionyl)acetate obtained in Step 1 above and 44.5 g of 2-chloro-5-[2-(2,4-di-tert-amylphenoxy)butyramido]aniline was stirred in an oil bath at 150° C for 3 hours under a reduced pressure of 50 to 100 mmHg. The reaction mixture was recrystallized from ligroin to yield 51 g (yield 83%) of Coupler (1) having a melting point of 65° to 68° C.

Provenance & Evidence