HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 241953Generated: October 25, 2026
Hydrazine → 7-(4-Chloro-1-methyl-1H-pyrazolo[3,4-b]pyridin-6-yl)-1H-indazol-3-amine
https://huagongshe.com/reaction/241953
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrazine | HCID 9321 | — |
| Reactant | 3-(4-Chloro-1-methyl-1H-pyrazolo[3,4-b]pyridin-6-yl)-2-fluorobenzonitrile | HCID 58083236 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | 7-(4-Chloro-1-methyl-1H-pyrazolo[3,4-b]pyridin-6-yl)-1H-indazol-3-amine | HCID 58083238 | — |
Reaction Steps
Hydrazine (0.34 mL, 1.04 mmol) was added to a solution of 3-(4-chloro-1-methyl-1H-pyrazolo[3,4-b]pyridin-6-yl)-2-fluorobenzonitrile 15 (0.030 g, 0.1046 mmol) in n-butanol and the reaction mixture was heated at 90° C. for 1 hour. The solvent was removed and diluted with ethylacetate, washed with saturated bicarbonate solution followed by brine. Drying and concentration gave 16.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08653098B2 |
|---|
| Source dataset | uspto-grants-2014_02 |
|---|
| ORD ID | ord-b89673042fb84568ab134fb1ccfc6552 |
|---|
| Source note | uspto-grants-2014_02 |
|---|
