反应详情

温度

200 °C

In the apparatus described in Example 1, 12.7 g of 4-trichloromethylbenzoic acid methyl ester (0.05 mol) and 7.5 g of 3-amino-4-hydroxybenzoic acid (0.05 mol) were mixed and heated for 6 hours at 200° C. The reaction product after grinding in a mortar was extracted twice with 100 ml of CHCl3 and then, after drying, twice with 100 ml of water. 9.2 g of raw product remained, melting at 275° to 284° C (62% of the theory). After two recrystallizations with dimethyl formamide plus active charcoal and dimethylsulfoxide, the melting point was 291° to 293° C.

1. additionwere mixed
2. customThe reaction product after grinding in a mortar
3. extractionwas extracted twice with 100 ml of CHCl3
4. dry with materialafter drying, twice with 100 ml of water
5. customAfter two recrystallizations with dimethyl formamide plus active charcoal and dimethylsulfoxide