Methane → HCID 86735944, compound

Participants

Reaction Steps

A mixture of 5.2 g of 5-(3α,12α-diformyloxy-5β-pregnane-20-yl)-trans-2-pentenoic acid methyl ester and 30 ml of 5 N aqueous sodium hydroxide was added and the mixture heated to reflux. The solution was then cooled, treated with charcoal and filtered with suction through a bed of diatomaceous earth. The filtrate was then cooled to 0° and with stirring was acidified to a pH3 by the dropwise addition of concentrated hydrochloric acid. The resulting precipitate was filtered and air dried overnight under house vacuum. Crystallization from methyl ethyl ketone gave 3 g of 5-(3α,12α-dihydroxy-5β-pregnane-20-yl)-trans-2-pentenoic acid, mp 204°-208°.

Provenance & Evidence