HCID 86735945, compound → HCID 86735946, compound

Participants

Reaction Steps

A mixture of 1 g of 10% Pd/C and 7.6 g of 5-(3α,12α-diformyloxy-5β-pregnane-20-yl)-trans-2-pentenoic acid methyl ester in 100 ml of ethyl acetate was hydrogenated at atmospheric pressure. After completion of the reaction, the catalyst was filtered and the solvent removed under reduced pressure. Trituration of the residue with ether-hexane afforded 7.5 g of 5-(3α,12α-diformyloxy-5β-pregnane-20-yl)-pentanoic acid methyl ester mp 67-72°.

Provenance & Evidence