Nitric Acid → 5-Methyl-2-n-propyl-4-imidazolecarboxaldehyde

HRID 2419652Notes

Reaction equation

HRID 2419652 reaction equation
[CH3:1][C:2]1[NH:6][C:5]([CH2:7][CH2:8][CH3:9])=[N:4][C:3]=1[CH2:10][OH:11].[N+]([O-])(O)=O>>[CH3:1][C:2]1[NH:6][C:5]([CH2:7][CH2:8][CH3:9])=[N:4][C:3]=1[CH:10]=[O:11]

Participants

3

Reactant 2

HCID 944Nitric AcidHCID 12493277HCID 12493277, compound

Product 1

HCID 124932825-Methyl-2-n-propyl-4-imidazolecarboxaldehyde

Procedure

An 80 gm. portion of 5-methyl-2-n-propyl-4-imidazolemethanol is oxidized with 67.3 ml. of concentrated HNO3. A second portion of 101.4 gm. of the above compound is oxidized with 77 ml. of the acid. The reaction mixtures are combined, neutralized and worked up as in Example 11, giving the desired product, m.p. 126°-129° C.

Workup

  1. customThe reaction mixtures

Sources & evidence

ORD record
ord-44a098104f264f14ab2aa6a37d15ba72
Source dataset
uspto-grants-1978_08
Patent number
US04107308

Reaction notes

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