Methyl iodide → HCID 12493309, compound

HRID 2419661Notes

Reaction equation

HRID 2419661 reaction equation
[CH:1]1[C:2]2[N:3]([CH:8]=[N:9][CH:10]=2)[C:4](=[S:7])[NH:5][N:6]=1.[CH3:11][O-].[Na+].CI>C(O)C>[CH3:11][S:7][C:4]1[N:3]2[CH:8]=[N:9][CH:10]=[C:2]2[CH:1]=[N:6][N:5]=1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 10942334Sodium MethoxideHCID 12493298HCID 12493298, compound

Product 1

HCID 12493309HCID 12493309, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
0 °C

Procedure

To 1.52 gm. of imidazo[1,5-d]-as-triazine-4(3H)-thione in 25 ml. of ethanol is added 0.54 gm. of sodium methoxide. Then 0.63 ml. of methyl iodide is added and the mixture is stirred and heated under reflux for 80 minutes. The mixture is cooled to 0° C. giving a precipitate which is collected. This product is recrystallized from 25 ml. of methanol and treated with charcoal giving the desired product, m.p. 186°-190° C.

Workup

  1. temperatureheated
  2. temperatureunder reflux for 80 minutes
  3. customgiving a precipitate which
  4. customis collected
  5. customThis product is recrystallized from 25 ml
  6. additionof methanol and treated with charcoal giving the desired product, m.p. 186°-190° C.

Sources & evidence

ORD record
ord-ddb6e36ba44b4f0a8940a974ceef9958
Source dataset
uspto-grants-1978_08
Patent number
US04107308

Reaction notes

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