HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 241972Generated: October 27, 2026
Potassium Carbonate → 6-(2-methoxypyridin-4-yl)-1-methyl-4-(4-(methylsulfonyl)phenoxy)-1H-pyrazolo[3,4-b]pyridine
https://huagongshe.com/reaction/241972
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-(Methylsulfonyl)phenol | HCID 123350 | — |
| Reactant | 4-chloro-6-(2-methoxypyridin-4-yl)-1-methyl-1H-pyrazolo[3,4-b]pyridine | HCID 58083239 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-(2-methoxypyridin-4-yl)-1-methyl-4-(4-(methylsulfonyl)phenoxy)-1H-pyrazolo[3,4-b]pyridine | HCID 46218671 | 50.2% |
Reaction Steps
To 4-chloro-6-(2-methoxypyridin-4-yl)-1-methyl-1H-pyrazolo[3,4-b]pyridine (0.4 g) and 4-(methylsulfonyl)phenol (0.5 g) was added DMF (3.4 mL) and potassium carbonate (1.0 g). Nitrogen was bubbled through the solution for 5 min. The reaction mixture was heated in a microwave reactor for 1 h at 150° C., then purified by reverse phase HPLC to provide 118 (0.3 g). MS (ESI) m/z 411.1 (M+1)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08653098B2 |
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| Source dataset | uspto-grants-2014_02 |
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| ORD ID | ord-f564b0af582a49b6b95df2b362530df0 |
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| Source note | uspto-grants-2014_02 |
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