Pyridinium chloride → HCID 13058962, compound

HRID 2419764Notes

Reaction equation

HRID 2419764 reaction equation
[CH2:1]([CH:3]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([O:12]C)[CH:10]=2)[CH2:5][CH2:4]1)[CH3:2].Cl.N1C=CC=CC=1>O>[CH2:1]([CH:3]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([OH:12])[CH:10]=2)[CH2:5][CH2:4]1)[CH3:2]

Participants

4

Reactant 2

HCID 10176127Pyridinium chlorideHCID 20314389HCID 20314389, compound

Product 1

HCID 13058962HCID 13058962, compoundYield 84.8%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
210 °C

Procedure

A mixture of 41 g of 3-ethyl-5-methoxy-indane and 111 g of pyridine hydrochloride was heated for 5 hours at 210° C. After it had cooled, 800 ml of water were added. The aqueous phase was extracted by shaking with chloroform. The combined organic phases were washed until neutral, and dried. Molecular distillation gave 32 g of 3-ethyl-5-hydroxy-indane; boiling point : 144° C/10 mm Hg. ##STR29##

Workup

  1. temperatureAfter it had cooled
  2. extractionThe aqueous phase was extracted
  3. washThe combined organic phases were washed until neutral, and
  4. customdried
  5. distillationMolecular distillation

Sources & evidence

ORD record
ord-0345b2eee8a242a0a35fe079fd1d173b
Source dataset
uspto-grants-1978_08
Patent number
US04107324

Reaction notes

Loading…