Benzylamine → HCID 20569835, compound

HRID 2419785Notes

Reaction equation

HRID 2419785 reaction equation
[IH:1].[CH2:2]([N:4]=[C:5](SC)[NH:6][NH2:7])[CH3:3].[CH2:10]([NH2:17])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>O>[IH:1].[NH2:7][NH:6][C:5]([NH:4][CH2:2][CH3:3])=[N:17][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

4

Reactant 2

HCID 7504BenzylamineHCID 86735929HCID 86735929, compound

Product 1

HCID 20569835HCID 20569835, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 25.0 g. of methyl N-ethylthiocarbazimidate hydroiodide and 10.2 g. of benzylamine in 150 ml. of water is heated on a steam bath for one hour and then evaporated under reduced pressure. The residue is dissolved in ethanol, treated with activated charcoal, filtered and evaporated under reduced pressure. The residue is dissolved in methylene chloride and the solution is passed through hydrous sodium magnesium silicate and concentrated under reduced pressure, giving the desired product as a residual red oil.

Workup

  1. customevaporated under reduced pressure
  2. dissolutionThe residue is dissolved in ethanol
  3. additiontreated with activated charcoal
  4. filtrationfiltered
  5. customevaporated under reduced pressure
  6. dissolutionThe residue is dissolved in methylene chloride
  7. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-0b74e436bb724faa802f3c106c475a3c
Source dataset
uspto-grants-1978_08
Patent number
US04107326

Reaction notes

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