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A solution of 1.34 g. of 2,6-dimethylbenzaldehyde [G. Lock and K. Schmidt, J. Prakt. Chem., 140, 229 (1934) and 2.92 g. of 1-amino-3-benzylguanidine hydroiodide in 25 ml. of absolute ethanol is heated at reflux for 18 hours. The solution is evaporated under reduced pressure to give a syrup which is made alkaline with aqueous NaOH. The mixture is extracted with chloroform. The chloroform extract is evaporated under reduced pressure to give a yellow syrup. Trituration of this syrup with diethyl ether and n-hexane, followed by filtration, gives the desired product as light pink crystals, m.p. 125°-126° C.

1. temperatureat reflux for 18 hours
2. customThe solution is evaporated under reduced pressure
3. customto give a syrup which
4. extractionThe mixture is extracted with chloroform
5. extractionThe chloroform extract
6. customis evaporated under reduced pressure
7. customto give a yellow syrup
8. filtrationTrituration of this syrup with diethyl ether and n-hexane, followed by filtration