反应详情

A mixture of 2.68 g. of 3,4-dimethylbenzaldehyde and 5.84 g. of 1-amino-3-benzylguanidine hydroiodide [W. J. Finnegan, R. A. Henry and E. Lieber, J. Org. Chem., 18, 779 (1953)] in 30 ml. of 66% aqueous ethanol is heated under reflux for 3 hours and then allowed to cool and crystallize. Filtration gives nearly colorless crystals which are recrystallized from aqueous ethanol, giving the desired product as cream-colored crystals, m.p. 183°-185° C.

1. additionA mixture of 2.68 g
2. temperatureunder reflux for 3 hours
3. temperatureto cool
4. customcrystallize
5. filtrationFiltration
6. customgives nearly colorless crystals which
7. customare recrystallized from aqueous ethanol