Bis(2-amino-1H-imidazole) sulphate → HCID 178522545, compound

HRID 2419800Notes

Reaction equation

HRID 2419800 reaction equation
[OH:1][C:2]1[C:11]2[C:6](=[C:7]([C:12]([F:15])([F:14])[F:13])[CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][C:3]=1[C:16](Cl)=[O:17].S(O)(O)(=O)=O.[NH2:24][C:25]1[NH:26][CH:27]=[CH:28][N:29]=1>>[NH:26]1[CH:27]=[CH:28][N:29]=[C:25]1[NH:24][C:16]([C:3]1[CH:4]=[N:5][C:6]2[C:11]([C:2]=1[OH:1])=[CH:10][CH:9]=[CH:8][C:7]=2[C:12]([F:15])([F:14])[F:13])=[O:17]

Participants

3

Reactant 2

HCID 135136Bis(2-amino-1H-imidazole) sulphateHCID 178521124HCID 178521124, compound

Product 1

HCID 178522545HCID 178522545, compoundYield 39.7%

Procedure

Using the procedure of Example 1, 11.57 g of 4-hydroxy-8-trifluoromethyl-quinoline-3-carboxylic acid chloride were reacted with 5.52 g of 2-aminoimidazole sulfate to obtain 3.9 g of N-(1H-imidazol-2-yl)-4-hydroxy-8-trifluoromethyl-quinoline-3-carboxamide melting at 211° C.

Sources & evidence

ORD record
ord-ad76f85e91894004b9ccdd5774896c59
Source dataset
uspto-grants-1978_08
Patent number
US04107310

Reaction notes

Loading…