Thionyl Chloride → HCID 178438811, compound

HRID 2419802Notes

Reaction equation

HRID 2419802 reaction equation
S(Cl)([Cl:3])=O.[OH:5][C:6]1[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([CH:16]([CH3:18])[CH3:17])[CH:14]=2)[N:9]=[CH:8][C:7]=1[C:19]([OH:21])=O>C1C=CC=CC=1>[OH:5][C:6]1[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([CH:16]([CH3:18])[CH3:17])[CH:14]=2)[N:9]=[CH:8][C:7]=1[C:19]([Cl:3])=[O:21]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 178438814HCID 178438814, compound

Product 1

HCID 178438811HCID 178438811, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

3.8 ml of thionyl chloride were added to a suspension of 10 g of the raw product of Step C in 300 ml of anhydrous benzene and the mixture was refluxed for 21/2 hours and was then cooled. The mixture was vacuum filtered and the precipitate was empasted with a little anhydrous benzene to obtain 10.74 g of 4-hydroxy-6-isopropyl-quinoline-3-carboxylic acid chloride melting at 252° C.

Workup

  1. temperaturethe mixture was refluxed for 21/2 hours
  2. temperaturewas then cooled
  3. filtrationfiltered

Sources & evidence

ORD record
ord-8278ed367e5d491c9aa5171a46f1dc27
Source dataset
uspto-grants-1978_08
Patent number
US04107310

Reaction notes

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