HCID 86735939, compound → HCID 178468992, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 53 g of the product of Step C and 50 ml of phenyl oxide was heated for 20 minutes in a bath at 240° C and the resulting ethanol was distilled. The phenyl oxide was evaporated and the residue was taken up in 100 ml of isopropyl ether. The mixture was filtered and the filter was washed twice with 10 ml of isopropyl ether to obtain 19 g of ethyl 4-hydroxy-2-ethyl-8-trifluoromethyl-quinoline-3-carboxylate melting at 129° C which was used as is for the next step.

Provenance & Evidence