HCID 178468890, compound → HCID 178439957, compound

Participants

Reaction Steps

A solution of 14 g of the product of Step D, 75 ml of 36° Be sodium hydroxide and 150 ml of ethanol was refluxed for 6 hours and was then cooled. The ethanol was distilled and 150 ml of ice water were added. The mixture was washed with methylene chloride and was acidified with slow addition of 2N hydrochloric acid at less than 15° C. The mixture was filtered and washed until the wash waters had a pH of 6 to obtain 6.9 g of 4-hydroxy-2-isopropyl-8-trifluoromethyl-quinoline-3-carboxylic acid melting at 204° C which was used as is for the next step.

Provenance & Evidence