2-(Trifluoromethyl)aniline → N-[2-(Trifluoromethyl)phenyl]butanamide

HRID 2419818Notes

Reaction equation

HRID 2419818 reaction equation
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:9]=[CH:8][CH:7]=[CH:6][C:4]=1[NH2:5].[C:12](Cl)(=[O:16])[CH2:13][CH2:14][CH3:15]>>[F:1][C:2]([F:10])([F:11])[C:3]1[CH:9]=[CH:8][CH:7]=[CH:6][C:4]=1[NH:5][C:12](=[O:16])[CH2:13][CH2:14][CH3:15]

Participants

3

Reactant 2

HCID 69222-(Trifluoromethyl)anilineHCID 8855Butyryl chloride

Product 1

HCID 3557464N-[2-(Trifluoromethyl)phenyl]butanamideYield 52.8%

Procedure

Using the procedure of Step A of Example 6, 32.2 g of o-trifluoromethylaniline and 23.44 g of butyryl chloride were reacted to obtain 24.4 g of N-(2-trifluoromethylphenyl)-butanamide melting at 76° C which was used as is for the next step.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-ca30d8ec23274c73aee119d371e178b7
Source dataset
uspto-grants-1978_08
Patent number
US04107310

Reaction notes

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