HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → Ethyl 2-diazo-3-(2,6-difluorophenyl)-3-oxopropanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-Acetamidobenzenesulfonyl azide | HCID 5129185 | — |
| Reactant | Ethyl 3-(2,6-difluorophenyl)-3-oxopropanoate | HCID 13550002 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Ethyl 2-diazo-3-(2,6-difluorophenyl)-3-oxopropanoate | HCID 86681842 | — |
Reaction Steps
Ethyl 3-(2,6-difluorophenyl)-3-oxopropanoate (12.3 g, 53.8 mmol) and triethylamine (22.5 mL, 0.161 mol, 3.0 equiv) were dissolved in acetonitrile (160 mL) and treated with 4-acetamidobenzenesulfonyl azide. The mixture was stirred for 18 hours at ambient temperature, concentrated in vacuo and the residue was purified by silica gel chromatography (eluting with chloroform), providing the titled compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08653079B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-e0f28b7b3da446fe96e04a73dd325fa2 |
| Source note | uspto-grants-2014_02 |