2-(Trifluoromethyl)aniline → N-[2-(trifluoromethyl)phenyl]pentanamide

HRID 2419821Notes

Reaction equation

HRID 2419821 reaction equation
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:9]=[CH:8][CH:7]=[CH:6][C:4]=1[NH2:5].[C:12](Cl)(=[O:17])[CH2:13][CH2:14][CH2:15][CH3:16]>>[F:1][C:2]([F:10])([F:11])[C:3]1[CH:9]=[CH:8][CH:7]=[CH:6][C:4]=1[NH:5][C:12](=[O:17])[CH2:13][CH2:14][CH2:15][CH3:16]

Participants

3

Reactant 2

HCID 69222-(Trifluoromethyl)anilineHCID 61186Valeryl chloride

Product 1

HCID 2274751N-[2-(trifluoromethyl)phenyl]pentanamideYield 42.1%

Procedure

Using the procedure of Step A of Example 6, 32.22 g of o-trifluoromethyl aniline and 26.52 g of valeryl chloride were reacted to form 20.63 g of N-(2-trifluoromethylphenyl)-pentanamide melting at 63° C which was used as is for the next step.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-ba613dbcba8346469e6b328d0e847a2d
Source dataset
uspto-grants-1978_08
Patent number
US04107310

Reaction notes

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