2-(Trifluoromethyl)aniline → 2-phenyl-N-[2-(trifluoromethyl)phenyl]acetamide

Participants

Reaction Steps

Using the procedure of Step A of Example 6, 40.28 g of o-trifluoromethyl aniline and 42.5 g of phenylacetyl chloride were reacted in the presence of 27.83 g of triethylamine in 400 ml of benzene to obtain 29.85 g of N-(2-trifluoromethylphenyl)-benzeneacetamide melting at 104° C after crystallization from hexane which was used as is for the next step.

Provenance & Evidence