反应详情

A mixture of 2-(4-chlorobenzyloxy)-3,3,3-trifluoro-2-trifluoromethylpropionitrile (20 g.), potassium hydroxide (25 g.), ethanol (250 ml.) and water (250 ml.) is heated under reflux for 15 minutes. Most of the ethanol is evaporated in vacuo, and the residue is cooled until the precipitated oil solidifies. The solid is filtered off, and is recrystallised from a mixture of ether and light petroleum (b.p. 40°-60° C.) (charcoal) to give 2-(4-chlorobenzyloxy)-3,3,3-trifluoro-2-trifluoromethylpropionamide, m.p. 94°-95° C. (13.9 g.).

1. temperatureis heated
2. temperatureunder reflux for 15 minutes
3. customMost of the ethanol is evaporated in vacuo
4. temperaturethe residue is cooled until the precipitated oil
5. filtrationThe solid is filtered off
6. customis recrystallised from a mixture of ether and light petroleum (b.p. 40°-60° C.) (charcoal)