Sodium Hydroxide → HCID 86735170, compound

HRID 2419924Notes

Reaction equation

HRID 2419924 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:24]=[CH:23][C:11]([CH2:12][O:13][C:14]([CH3:22])([C:18]([F:21])([F:20])[F:19])[C:15]([OH:17])=[O:16])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[OH-].[Na+:26]>O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[CH:10][C:11]([CH2:12][O:13][C:14]([CH3:22])([C:18]([F:19])([F:20])[F:21])[C:15]([O-:17])=[O:16])=[CH:23][CH:24]=2)=[CH:6][CH:7]=1.[Na+:26]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 13384277HCID 13384277, compound

Product 1

HCID 86735170HCID 86735170, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of (±)-2-[4-(4-chlorophenyl)benzyloxy]-3,3,3-trifluoro-2-methylpropionic acid (0.36 g.), N aqueous sodium hydroxide (1.0 ml.) and water (3.0 ml.) is stirred until no more of the acid dissolves. The mixture is filtered, the filtrate is washed with ether and evaporated in vacuo. The residue is crystallised from a mixture of ethyl acetate and light petroleum (b.p. 60°-80° C.) to give (±)-sodium 2[4-(4-chlorophenyl)benzyloxy]-3,3,3-trifluoro-2-methylpropionate (0.3 g.) m.p. 271°-272° C. (decomposition).

Workup

  1. dissolutiondissolves
  2. filtrationThe mixture is filtered
  3. washthe filtrate is washed with ether
  4. customevaporated in vacuo
  5. customThe residue is crystallised from a mixture of ethyl acetate and light petroleum (b.p. 60°-80° C.)

Sources & evidence

ORD record
ord-6a4e6a0102f640e79ab17e070a35da79
Source dataset
uspto-grants-1978_08
Patent number
US04107329

Reaction notes

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