Potassium Hydroxide → HCID 13384291, compound

HRID 2419931Notes

Reaction equation

HRID 2419931 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([CH2:13][O:14][C:15]([CH3:24])([C:20]([F:23])([F:22])[F:21])[C:16]([O:18]C)=[O:17])[CH:7]=[CH:6]2.[OH-].[K+].[OH-].[Na+]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([CH2:13][O:14][C:15]([CH3:24])([C:20]([F:21])([F:22])[F:23])[C:16]([OH:18])=[O:17])[CH:7]=[CH:6]2

Participants

4

Reactant 3

HCID 14797Potassium HydroxideHCID 14798Sodium HydroxideHCID 13384290HCID 13384290, compound

Product 1

HCID 13384291HCID 13384291, compound

Procedure

The process of Example 17 is repeated using (±)-methyl 2-(6-methoxy-2-naphthylmethoxy)-3,3,3-trifluoro-2-methylpropionate, obtained as an oil in Example 43, as starting material except that the potassium hydroxide is replaced by 4.4 N aqueous sodium hydroxide and the reaction is carried out for 21/2 hours to give (±)-2-(6-methoxy-2-naphthylmethoxy)-3,3,3-trifluoro-2-methylpropionic acid, m.p. 117°-119° C. (from light petroleum b.p. 60°-80° C.).

Workup

  1. customobtained as an oil in Example 43
  2. custom2 hours

Sources & evidence

ORD record
ord-8caf91116177413a8a7b369832bef445
Source dataset
uspto-grants-1978_08
Patent number
US04107329

Reaction notes

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