1-Chloro-4-(chloromethyl)benzene → HCID 13384272, compound

HRID 2419934Notes

Reaction equation

HRID 2419934 reaction equation
[OH:1][C:2]([C:8]([F:11])([F:10])[F:9])([CH3:7])[C:3]([O:5][CH3:6])=[O:4].[Cl:12][C:13]1[CH:20]=[CH:19][C:16]([CH2:17]Cl)=[CH:15][CH:14]=1>>[Cl:12][C:13]1[CH:20]=[CH:19][C:16]([CH2:17][O:1][C:2]([CH3:7])([C:8]([F:9])([F:10])[F:11])[C:3]([O:5][CH3:6])=[O:4])=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 77231-Chloro-4-(chloromethyl)benzeneHCID 13384224Methyl 3,3,3-trifluoro-2-hydroxy-2-methylpropanoate

Product 1

HCID 13384272HCID 13384272, compound

Procedure

In a similar manner, but starting from (±)-methyl 2-hydroxy-2-trifluoromethylpropionate (8.6 g.) and 4-chlorobenzyl chloride (8.05g.), there is obtained (±)-methyl 2-(4-chlorobenzyloxy)-3,3,3-trifluoro-2-methylpropionate as an oil (8.0g.), b.p. 92°-98° C. (0.1 mm.Hg.).

Sources & evidence

ORD record
ord-4759bbffa8c241978292d2faf1c2abe2
Source dataset
uspto-grants-1978_08
Patent number
US04107329

Reaction notes

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